The Palace Theatre is home to the Westmoreland Symphony Orchestra and a regional venue for River City Brass. Productions are mounted on a regular basis by local groups including Laurel Ballet, Stage Right and Big Brothers Big Sisters of the Laurel Region. Concert promoters bring popular entertainers to the Palace such as Buddy Guy, Brian Regan, Robin Trower, Lee Greenwood, Eddie Money, Third Eye Blind, Bill Cosby, The Jonas Brothers, The Oak Ridge Boys, Frankie Avalon, Jackson Browne, The Beach Boys, and Keb Mo.

Westmoreland Cultural Trust, owner and developer of The Palace, sponsors national touring musicals and celebrity headliners like Kansas, Bill Cosby, Three Dog Night, Kenny Rogers, Craig Ferguson, Wayne Newton, David Brenner, The Bacon Brothers, Lily Tomlin, Bob Newhart, Neil Sedaka, Ben Vereen, Bernadette Peters, Harry Belafonte and Paul Anka.